Overview

Optimize your metabolite-based LC-MSⁿ screening and minimize false negative results

The Maurer/Wissenbach/Weber LC-MSⁿ Library of Drugs, Poisons, and Their Metabolites, Second Edition provides a proven metabolite-based LCMSⁿ screening method and MS² and MS³ spectra of over 2,270 parent compounds and over 3,600 of their metabolites, making it one of the only LC-MSⁿ screening libraries that focuses on metabolite spectra.

The second edition was developed for forensic and clinical research and routine labs to quickly and accurately confirm and identify drugs, poisons, and/or their metabolites. Detection of metabolites increases the sensitivity, detection window and selectivity, allows confirmation of the body passage, and minimizes the risk of false negative LC-MS results possibly caused by ion suppression of the target analyte. Even the risk of false positive results can be reduced considering the metabolite patterns.

LC-MSⁿ Library of Drugs, Poisons, and Their Metabolites, Second Edition includes instrument specific training inserts covering details on:

• Sample preparation methods
• Applied chromatographic conditions
• Applied MS settings

Library Specifications

Spectra: > 13,000
Structures: 10,787
Toxicologically Relevant Compounds: > 2,270
Metabolites/Artifacts: > 3,600
Endogenous Molecules/Impurities: 90 

Compatibility

See supported instrument file formats.

Compound Coverage

Compound coverage can be searched at www.compoundsearch.com.

Wissenbach DK, Meyer MR, Remane D, Weber AA, Maurer HH. Development of the first metabolite-based LC-MSⁿ urine drug screening procedure – exemplified for antidepressants. (2011) Anal Bioanal Chem. 400:79-88.

Wissenbach DK, Meyer MR, Remane D, Philipp AA, Weber AA, Maurer HH. Drugs of abuse screening in urine as part of a metabolite-based LC-MSⁿ screening concept. (2011) Anal Bioanal Chem. 400:3481-3489.