Overview

The essential GC-MS database. Trusted data, faster answers.

When accuracy has real consequences, you need data you can trust. The Wiley Registry of Mass Spectral Data is one of the world's largest and most trusted GC-MS libraries — relied on by laboratories worldwide where fast, accurate results are critical, including environmental science, forensics, pharmaceutical R&D, food safety, defense, QA/QC, and many more.

The 2026 release is the strongest yet with 915,500* expertly curated, high-quality GC-MS spectra, including over 42,000 new spectra — giving analysts the spectral intelligence to move from unknown to identified faster, with greater confidence.

Not just a database. The GC-MS intelligence your workflow needs. 

FoundationalProvenTrusted by labs worldwide

Now also available as a KnowItAll subscription for continued access to new data as it’s added to the collection.

Library Specifications

The Wiley Registry is also available as a KnowItAll subscription for continued access to new data between major releases.

Subscription content is subject to change as data may be added or deleted from collections periodically.

* previously Estimated Kovats retention indices

Features

• Comprehensive GC-MS coverage 915,500 expertly curated GC-MS spectra for targeted and non-targeted analyses across a wide range of applications.
• Authoritative data quality Data is rigorously reviewed by Wiley’s internal and external experts at every stage — from acquisition through publication.
• Quality Index (QI) scoring Spectra are assigned a Quality Index where possible, enabling searches to be tuned to exclude spectra below a quality index threshold.
• Rich, searchable metadata Every record includes searchable metadata where available — chemical structure, exact mass, computed RI values, and more — to narrow results beyond the spectrum alone and turn a spectral match into compound intelligence.
• Replicate spectra Spectra are segmented into separate libraries, including replicate spectra, ensuring robust results regardless of instrument or laboratory settings.
• Vendor-neutral compatibility Available in the most common manufacturer formats. Designed to fit into your existing workflow from day one – no reconfiguration required.
• KnowItAll subscription option Also available as a KnowItAll subscription for continued access to new spectra as they are added between major releases, with software integration for automated GC-MS workflows.

Applications

Laboratories face increasingly complex analytical challenges—from detecting emerging environmental contaminants to identifying novel substances in forensic investigations. As a result, having access to a comprehensive, rigorously validated spectral database has become foundational to getting results right.

This collection offers exceptional reliability as a comprehensive resource for the analysis, identification, classification, and verification of compounds by mass spectrometry in a wide range of applications such as:

What’s New in 2026

• Expanded compound coverage: This release adds over 42,000 spectra covering more than 34,100 newly included unique compounds.
• Authoritative data: Expanded content from labs, world patents, and peer-reviewed literature, including DOIs to source articles.
• Broader structure coverage: With chemical structures assigned to most GC-MS spectra, users can apply structure- and class-based search filters (including Markush-style queries) to target specific chemistries during identification.

Compatibility

• Available in the most common instrumentation manufacturer formats. See supported vendor formats
• Also available as a KnowItAll subscription for use with Wiley’s KnowItAll software, which supports multiple instrument vendor formats

Ordering Information

Need even more coverage?

Be sure to ask about our Wiley Registry/NIST and KnowItAll GC-MS Library packages with powerful tools to optimize and automate your workflow.