Overview

From the Leader in Spectral Data

Combine the power of two essential libraries for confident results

The Wiley Registry/NIST EI Mass Spectral Library is the most comprehensive combined mass spectral library commercially available, with over 1.2 million EI spectra making it the clear choice for general unknown compound identification.

This 2026 release brings together 1.2 million-plus searchable structures and over 1 million unique compounds, including more than 79,000 new spectra, giving analysts broader coverage and the confidence to move from unknown to identified faster.

The GC-MS intelligence your workflow needs. 

FoundationalProvenTrusted by laboratories worldwide

Library Specifications

*Wiley Registry/NIST EI database counts = Wiley Registry and NIST, minus any overlap. 

Unique EI compound coverage – Wiley Registry 2026 and NIST

Applications

Laboratories face increasingly complex analytical challenges—from detecting emerging environmental contaminants to identifying novel substances in forensic investigations. As a result, having access to a comprehensive, rigorously validated spectral database has become foundational to getting results right.

This collection offers exceptional reliability as a comprehensive resource for the analysis, identification, classification, and verification of compounds by mass spectrometry in a wide range of applications such as:

What’s New in this Release?

Take advantage of all the benefits in the 2026 release of this combined collection:

Be sure your lab is up to date with the latest release of this evolving collection.

Over 66,000 unique compounds and over 79,000 spectra were added, taking the collection to 1,016,700 unique compounds and 1,259,900 spectra.

Wiley Registry of Mass Spectral Data 2026

• Expanded compound coverage: This release adds over 42,000 spectra covering more than 34,100 newly included unique compounds.
• Authoritative data: Expanded content from labs, world patents, and peer-reviewed literature, including DOIs to source articles.
• Broader structure coverage: With chemical structures assigned to most GC-MS spectra, users can apply structure- and class-based search filters (including Markush-style queries) to target specific chemistries during identification.

NIST / EPA / NIH EI Mass Spectral Library 2026

• Expanded compound coverage: This release adds over 35,000+ new compounds, bringing the library to more than 431,000 EI spectra.
• Targeted relevance: new data places added emphasis on compounds that are biologically, environmentally, or industrially relevant.
• Broader retention index coverage: The GC Retention Index Library adds over 35,000 compounds.

Compatibility

Compatible with most current and legacy mass spectrometry data systems. For full compatibility information please visit sciencesolutions.wiley.com/compatibility.

Ordering Information