Studies suggest that Sargassum horneri can help prevent osteoporosis and control cholesterol, blood pressure and hyperlipidemia and cosmetics and functional foods containing S. horneri are known to have anti-aging, anti-allergic and whitening effects. Thus, the anti-neuroinflammatory effects of S. horneri extract on microglia were investigated. The active ingredient in S. horneri was confirmed using AntiBase, previously reported data, and LC-MS/MS analysis. S. horneri was found to elicit anti-neuroinflammatory effects by inhibiting phosphorylation of p38 MAPK and NF-κB and inhibited astrocytes and microglia activation in LPS-challenged mice brain.

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