Short-chain fatty acids (SCFAs) are gut-derived products present in the blood stream. In this work, it is shown using GC-MS on blood samples that patients with cirrhosis have decreased levels of SCFAs, and these decreased levels are associated with more advanced liver disease. The SCFAs were identified using both the retention times for standard compounds, and with standard spectra from the National Institute of Standards and Technology (NIST) Mass Spectral Library and the Wiley Registry of Mass Spectral Data.
View Case StudyCirculating levels of butyrate are inversely related to portal hypertension, endotoxemia, and systemic inflammation in patients with cirrhosis
Technique: GC-MS
Applications: Pharmaceutical & Biotech
Products: KnowItAll Software, NIST/EPA/NIH Mass Spectral Library, Wiley Registry
